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pentobarbital will decrease the extent or result of methylprednisolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will minimize the extent or impact of mifepristone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers haven't been researched, coadministration n